Trichoplein
Trichoplein keratin filament-binding protein is a protein that in humans is encoded by the TCHP gene.
Trichoplein
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WebJul 5, 2024 · Biomedicines 2024, 10, 1602 2 of 15 kinase Aurora A through a direct molecular interaction during centrioles activation at the G1‐phase, thus negatively regulating primary cilia assembly in this phase [5]. WebRecent investigations are focused on mitotic DNA damage response (DDR) and chromosome mis-segregations with the aim of developing more efficient anti-cancer therapies. We previously demonstrated that trichoplein keratin filament binding protein (TpMs) exhibits hallmarks of a tumor suppressor gene in cancer-derived cells and human …
WebJun 26, 2007 · Function. Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells ( By similarity ). WebName. trichoplein keratin filament-binding protein. Brite. KEGG Orthology (KO) [BR: ko00001] 09180 Brite Hierarchies. 09182 Protein families: genetic information processing. 03036 Chromosome and associated proteins. K16811 TCHP; trichoplein keratin filament-binding protein. Chromosome and associated proteins [BR: ko03036]
WebThus, the EGFR–USP8–trichoplein–AURKA axis suppresses ciliogenesis under serum cultivation, and serum deprivation downregulates the EGFR-USP8 pathway, which triggers trichoplein degradation and AURKA inactivation, resulting in ciliogenesis. These results were the first to reveal the mechanism of serum starvation–induced ciliogenesis. WebSep 26, 2016 · Instead, trichoplein depletion results in the elevation of p27 , one of CKIs (Fig. 2). P27 is known to increase during quiescent state but decrease during proliferation state [ 82 , 83 ]. Since CDK activities are also critical for the G0/G1 transition through the phosphorylation of pRb (the product of the retinoblastoma tumor suppressor gene) [ 89 – …
WebMar 15, 2011 · Trichoplein – a widely expressed keratin intermediate filament scaffold protein – is shown by Masaki Inagaki and co-workers on page 857 to have a key role in …
WebAutophagy is an evolutionarily conserved and tightly regulated process that plays an important role in maintaining cellular homeostasis. It involves regulation of various genes that function to degrade unnecessary or dysfunctional cellular components, and to recycle metabolic substrates. Autophagy is modulated by many factors, such as nutritional … dhss for missouriWebBritish Heart Foundation - Search results cincinnati public schools job fair 201Webtrichoplein (G-2): sc-515025 Santa Cruz Biotechnology, Inc. 1.800.457.3801 831.457.3800 fax 831.457.3801 Europe +00800 4573 8000 49 6221 4503 0 www.scbt.com … dhss health education unitWebDec 29, 2015 · Effects of trichoplein depletion on cell cycle regulators. Proliferating RPE1 cells were transfected with siRNA for control or trichoplein (#1 and #2), and then cultured for 72 h. The cell extracts were subjected to immunoblotting analysis with p27 Kip1, p53, p21 Cip1, p16 INK4a, trichoplein, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). cincinnati public schools leave maternityWebApr 30, 2012 · Trichoplein or Aurora A knockdown failed to induce ciliogenesis or cell cycle arrest in HeLa cells, which, like many cancerous cell types, have a reduced tendency to form primary cilia. “We're now investigating whether Aurora A knockdown has different effects in various normal and cancer cell lines,” says Inagaki. dhss hcbs rate increaseWebSep 1, 2024 · Trichoplein (TCHP) is a protein that impinges on the stability of axonemal microtubules and acts as a negative regulator of cilia assembly [70]. Upon binding of … dhss health.mo.govWebDive into the research topics where David Mellis is active. These topic labels come from the works of this person. Together they form a unique fingerprint. 1 Similar Profiles. P62 Chemical Compounds. 100%. anillin Medicine & Life Sciences. 85%. Endothelial Cells Medicine & Life Sciences. cincinnati public schools number