2024 Gata3 and breast cancer

Gata3 and breast cancer

Author: ymtw

August undefined, 2024

WebGATA3, a transcription factor that regulates T lymphocyte differentiation and maturation, is exclusively expressed in early stage well differentiated breast cancers but not in advanced invasive cancers. However, little is …

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WebNov 12, 2024 · GATA3 has been shown to be associated with the luminal subtype of breast cancer, whereas 88% of estrogen receptor (ER)-negative tumors retained GATA3 … WebGATA3 in particular is necessary for mammary gland maturation, and its loss has been implicated in breast cancer development. Our goal was to validate the ability of GATA3 … packer division

Higher levels of GATA3 predict better survival in women with breast cancer.

WebWe performed a survival analysis of 989 breast cancer patients from The Cancer Genome Atlas (TCGA), and validated the findings in 202 breast cancer patients from tissue … WebOct 25, 2024 · When combining GATA3, TRPS1, and MGP, we observed that 797/1201 (66.4%) of the enrolled breast carcinoma cases were positive for all three markers, including 452/565 (80.0%), 238/352 (67.6%), and 107/284 (37.7%) in the ER/PR+, HER2+, and TNBC subgroups, respectively (Table 3, Figs. 4 and 5 ). WebTriple-negative breast cancer (TNBC) patients have an increased risk of developing visceral metastases and other primary nonbreast cancers, particularly lung cancer. ... GATA3 had moderate sensitivity (30.4%) and excellent specificity (98.7%) and misclassified only 2/152 LA (1.3%). GCDFP15 had a moderate sensitivity (20.8%) and excellent ... packer disk_additional_size

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GATA-3 expression in breast cancer is related to intratumoral M2 ...

WebThe GATA3 expression was closely associated with tumor size as well as metastasis. GATA3 significantly suppressed OS cells proliferation, migration and invasion. EMT … WebMicroarray analysis of two normal and seven breast cancer samples found 129 genes with >fivefold changes. Further SAGE and EST analyses of these genes identified four … jersey crew neck jumperWebJun 1, 2009 · GATA3 expression inhibits breast tumor outgrowth and spontaneous lung metastasis. To test the hypothesis that GATA3 can negatively regulate the ability of … jersey cudweed australia

"WebJul 1, 2024 · TRPS1, GATA3, and SOX10 expression (x10) in representative cases of triple-negative invasive breast carcinoma of no special type (IBC-NST). Case 1 shows a triple-negative IBC-NST with high expression of TRPS1 and GATA3 and negative expression of … " - Gata3 and breast cancer

Gata3 and breast cancer

GATA3 expression in breast carcinoma: utility in triple …

Web21 hours ago · GATA3 is a transcription factor that is frequently mutated in breast cancers. Dr. Takaku’s group has developed a novel assay to investigate GATA3 functions and the mechanisms through which... WebSep 17, 2024 · GATA3 mutations are known to play an important role in breast cancer progression. The exact role and mechanisms of these mutations remain controversial as some studies suggest a relation to breast tumor growth, while others suggest a relation to longer survival. GATA3 germline mutations are not well studied in breast cancer.

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WebMar 4, 2024 · GATA3 acts as a suppressor in breast cancer metastasis, for it can mediate the reversal of epithelial-mesenchymal transition and thus promotes epithelial differentiation of invasive cancer cells [ 18, 19 ]. Further, GATA3 is also involved in the development of nervous system [ 20 ], kidney [ 21 ], and skin [ 22 ]. WebMar 30, 2024 · GATA binding protein 3 (GATA-3) is a differentiation marker related to differentiated states in breast cancer. In this study, we explore how the extent of MI relates to GATA-3 expression, hormonal status, and the differentiation grade of breast cancer.

WebApr 14, 2024 · C-X-C motif chemokine ligand 1 (CXCL1) is a member of the CXC chemokine subfamily and a ligand for CXCR2. Its main function in the immune system is the … WebThis real-world cohort analysis assessed the efficacy of alpelisib and endocrine treatment (ET) combinations in a post-everolimus setting. Thirteen women who started alpelisib and ET at standard doses between 2024 and 2024 for advanced breast cancer (ABC), after undergoing CDK4/6i and everolimus treatment, were eligible for the study entry. The …

WebMicroarray analysis of two normal and seven breast cancer samples found 129 genes with >fivefold changes. Further SAGE and EST analyses of these genes identified four qualified genes, ERBB2, GATA3, AGR2, and ANXA1. Their expression pattern was validated by RT-PCR in both breast cell lines and tissue samples. Loss of ANXA1 in breast cancer was ... WebDec 9, 2024 · CTSV expression is associated with a poor survival in ER-positive breast cancers. To determine if there was a clinical association between CTSV expression and …

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WebWhat is GATA3 positive breast cancer? GATA3 is a transcription factor closely associated with estrogen receptor alpha in breast carcinoma, with a potential prognostic utility. This study investigated the immunohistochemical expression of GATA3 in estrogen receptor alpha-positive and estrogen receptor alpha-negative breast carcinomas. jersey cricket clubWebGATA3 is used predominantly to support the diagnosis of breast or urothelial origins in a carcinoma of unknown primary. GATA3 expression has been observed in 48–94% of breast carcinomas [1], [2], [3], [4]. In particular, the co-expression of CK7, GATA3, and ER is highly suggestive of breast cancer. jersey cudweed londonWeb14 GATA3 expression seems to be more extensive in lower grade tumors and positive cases, and cases with high expression may have a better survival 14,15 However, none of those studies have assessed the specificity of GATA3 for breast cancer. In another study, strong expression of GATA3 (in >50% tumor cells) was detected only in mammary (94% ... packer directoryWebApr 8, 2024 · Breast cancer is a heterogeneous disease with different molecular subtypes. Breast cancer is the second leading cause of mortality in woman due to rapid metastasis and disease recurrence. Precision medicine remains an essential source to lower the off-target toxicities of chemotherapeutic agents and maximize the patient benefits. This is a … packer disk_controller_type vmwareWebGATA3 is one of the three genes mutated in >10% of breast cancers (Cancer Genome Atlas). [29] Studies in mice indicate that the gene is critical for the normal development of … jersey cricket resultsWebWe performed a survival analysis of 989 breast cancer patients from The Cancer Genome Atlas (TCGA), and validated the findings in 202 breast cancer patients from tissue microarray (TMA). Results In TCGA database, the mRNA expression of GATA3 and ZNF503 could not predict TNBC prognosis alone, though the ratio index, … packer direct leatherWebGATA3 is a member of a family of zinc-finger transcription factors present in vertebrate organisms and involved in the differentiation of breast epithelia, urothelia, and a subset of T lymphocytes. 8 A previous study identified 5 patients with GATA3 gene mutations among 111 individuals with breast cancer; however, none of them had HDR syndrome ... packer discord pfp