WebApr 24, 2024 · Detailed Description: The purpose of this study is to evaluate the effectiveness of cholesterol/lovastatin versus lovastatin alone to treat porokeratosis. … WebAug 1, 2024 · Recent evidence has demonstrated the efficacy of a pathogenesis-based topical therapy with combined lovastatin/cholesterol therapy in patients with DSAP, …
Topical Lovastatin new primary treatment option for patients of ...
WebCholesterol and lovastatin: DSP/DSAP, PPPD, LP: Bypass of mevalonate pathway mutations: 2% cholesterol/2% lovastatin ointment BID for up to 3 mo - None reported: N/A: IIB, 1 IV 2: 5-Fluorouracil: LP, PM, DSAP: Inhibition of thymidylate synthetase; cytotoxic: 5% 5-FU cream BID, duration of treatment ranging 7 wk to 3 mo Web1 day ago · Participants were randomized to once- or twice-daily application of either lovastatin-cholesterol cream (n = 17) or lovastatin cream (n = 14) to symptomatic regions for 12 weeks. The effect of the treatment on DSAP at the end of treatment (12 weeks) as measured by the DSAP General Assessment Severity Index (DSAP-GASI; scored from … fci lender services fax number
Porokeratosis: What Is It And How Does It Impact My Health? - WebMD
WebJan 13, 2024 · Disseminated superficial actinic porokeratosis (DSAP) The most common subtype of porokeratosis, DSAP usually appears in people in their 20s or 30s. It is more common in females than in males. WebApr 21, 2024 · Our working hypothesis is that both topical cholesterol/lovastatin and lovastatin alone are helpful in treating patients with disseminated superficial actinic … WebTo our knowledge, this is the first report of topical lovastatin/cholesterol as a treatment for this rare subtype of porokeratosis. Although the combined topical lovastatin/cholesterol did not lead to complete resolution of the patient’s lesions as noted in other variants of porokeratosis, treatment has steadily reduced the plantar papules ... fritz 8 download free