WebRecently they discovered that the RNA helicase DDX39B is a critical activator of IL7R exon 6 splicing and reduced levels of DDX39B, an activator of exon 6 inclusion, leads to increased production of soluble IL7R in cells in culture, and is associated with increased risk for MS in human populations. WebMay 15, 2024 · Purpose: The goal of this study is to investigate the role of DDX39B in RNA splicing Methods: RNA-Seq splicing analysis of HeLa cells with experimentally induced DDX39B expression knockdown : Overall design: DDX39B expression is reduced in HeLa cells by siRNAs. Effects on alternative RNA splicing are compared between knockdown …
UniProt
WebDDX39B (BAT1, D6S81E, UAP56) protein expression summary. ... The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of ... Webwhen a splice donor is joined with an upstream splice ac-ceptor via “backsplicing” (Ebbesen et al. 2016). circRNA levels are regulated by several factors, including RNA-binding proteins, exon-skipping events, the presence of complementary sequences of flanking introns, and the availability of splicing machinery components (Wilusz 2024). alcatrazz dvd
DDX39B protein expression summary - The Human Protein Atlas
WebJan 29, 2024 · DDX39B was upregulated in relapsed JDCaP xenografts expressing AR splice variants, suggesting its role in expression of AR splice variants. Taken together, our findings offer insight into the mechanisms of AR splice variant generation and identify DDX39 as a potential drug target for the treatment of AR splice variant-positive prostate … WebDDX39B: Spliceosome RNA helicase DDX39B; Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to … WebMar 21, 2024 · Complete information for DDX39B gene (Protein Coding), DExD-Box Helicase 39B, including: function, proteins, disorders, pathways, orthologs, and … alcatrazz – disturbing the peace